18 research outputs found
Chronic Discoid Lupus: An uncommon cause of nail atrophy
Interesting Medical Imag
Erythematous Plaque in the Left Axillary Region: A diagnostic challenge where dermoscopy can help
NON
Validation of a Questionnaire to Assess the Perception of Women with Atopic Dermatitis in Family Planning
Introduction: Atopic dermatitis (AD) is a highly frequent chronic inflammatory skin
disease. It is important to know how women with AD approach family planning together with
their disease. The aim of the present research is to develop and validate a questionnaire for women
diagnosed with AD in order to measure their level of desire and gestational information. Materials
and Methods: A multicenter cross-sectional study was conducted. Women between 18 and 45 years
old with mild, moderate, and severe forms of the disease were included and disease-free controls. An
exploratory factorial analysis of the primary components and varimax rotation was used to measure
the validity of the construct. Cronbach’s α was used to measure the reliability of the individual
scales and the global questionnaire. Results: In total, 150 valid questionnaires were included. The
final questionnaire consisted of 23 items that converged on six factors. The six scales had adequate
reliability: “Pregnancy” (Cronbach’s alpha = 0.95), “Conception” (Cronbach’s alpha = 0.93), “Concern-
information” (Cronbach’s alpha = 0.82), “Breastfeeding” (Cronbach’s alpha = 0.81), “Sexual life”
(Cronbach’s alpha = 0.79), and “Family planning” (Cronbach’s alpha = 0.67). The total Cronbach’s
alpha of the questionnaire was 0.94. Discussion: This questionnaire is the first specific measurement
instrument developed for women with AD of childbearing age that has demonstrated adequate levels
of reliability and construct validity. We consider it useful and valuable to study aspects such as family
planning in this patient profile, and that can influence their decision to have offsprin
Photosensitive rash induced by nivolumab.
The therapeutic approach to metastatic melanoma has revolutionized the clinical course of this disease. Since 2011, different immunotherapeutic drugs have been approved. Nivolumab is a humanized immunoglobulin IgG4 monoclonal antibody that binds to the PD-1 receptor, blocking its interaction with his ligand PD-L1. The authors present a new case of photosensitivity induced by nivolumab. The photo exposed distribution of the eruption, the sun exposure prior to the beginning of the eruption, and the chronological relationship with the beginning of the treatment are data that have allowed us to confirm the suspected clinical diagnosis